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Kumar, Ravi
- Formulation and Evaluation of Fast Dissolving Tablets of Trimetazidine Dihydrochloride Using Natural and Synthetic Superdisintegrants
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Authors
Affiliations
1 Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmaceutics, Karavali College of Pharmacy, Mangalore, IN
3 Department of Pharmacognosy, Karavali College of Pharmacy, Vamanjoor, Mangalore, IN
1 Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmaceutics, Karavali College of Pharmacy, Mangalore, IN
3 Department of Pharmacognosy, Karavali College of Pharmacy, Vamanjoor, Mangalore, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 8, No 2 (2016), Pagination: 95-104Abstract
Plant products serve as an alternative to synthetic products because of local accessibility, eco friendly nature and lower price compared to imported synthetic products. Natural gums and mucilage have been widely explored as pharmaceutical excipients. Tablet disintegration has received considerable attention as an essential step in obtaining fast drug release. The present work was carried out to study the disintegration properties of Plantago Ovata mucilage powder by formulating orally disintegrating tablets of Trimetazidine hydrochloride by direct compression method. Disintegrant property of above disintegrants was evaluated by comparing their formulations with the formulations of various superdisintegrants extracted Mucilage was subjected to toxicity studies for its safety and preformulation studies for its suitability as a disintegrating agent. The extracted mucilage is devoid of toxicity. No chemical interaction between drug and excipients was confirmed by FTIR and DSC studies. Mouth dissolving tablets of Trimetazidine hydrochloride were prepared and compared with different concentrations viz; 0.5, 1, 1.5, 2.0 and 2.5% (w/w) of Plantago Ovata mucilage powder, cross carmellose sodium and sodium starch glycolate. Thirty six formulations were prepared by using different diluents and evaluated for physical parameters such as thickness, hardness, friability, weight variation, drug content, disintegration time and drug dissolution. The formulated tablets had good appearance and better drug release properties. The study revealed that Plantago Ovata mucilage powder was effective as disintegrant in low concentrations (1%). The mucilage was found to be a superior disintegrating agent than sodium starch glycolate and cross carmellose sodium. Studies indicate that the extracted mucilage may be a good source of pharmaceutical adjuvant, specifically a disintegrating agent.Keywords
Fast Dissolving Tablet, Trmetazidine Dihydrochloride, Superdisintegrant, Direct Compression, Plantago Ovate, Sodium Starch Glycolate, Cross Carmellose Sodium, Cross Povidone.- Formulation and Evaluation of Immediate Release Pravastatin Sodium Tablets
Abstract Views :235 |
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Authors
Affiliations
1 Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmaceutics, Karavali College of Pharmacy, Mangalore, IN
1 Karavali College of Pharmacy, Mangalore, IN
2 Department of Pharmaceutics, Karavali College of Pharmacy, Mangalore, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 8, No 2 (2016), Pagination: 105-118Abstract
The objective of this research was to formulate fast dissolving tablets of Pravastatin sodium that disintegrate in the oral cavity upon contact with saliva and there by improve therapeutic efficacy. Pravastatin sodium is used for the treatment of myocardial infarction. Fast dissolving tablets of pravastatin sodium were prepared by direct compression method using three different superdisintegrants-Sodium starch glycollate, Crosscarmellose sodium and Crosspovidone (2%, 4% and 6%) and three different diluents (mannitol and spray dried lactose) in different concentrations. Eighteen formulations were prepared by using different diluents and evaluated were evaluated for various pre and post compression parameters like angle of repose, bulk density, tapped density, compressibility index, Hausner's ratio, tablet hardness, friability, weight variation, wetting time, water absorption ratio in vitro dispersion time, drug content and in vitro dissolution studies. FTIR and DSC studies revealed that there was no chemical interaction between the drug and the excipients. Formulation L6 was found to be the best on the basis of wetting time, in vitro disintegration time and in vitro drug release. The formulation L6 containing spray dried lactose as diluent and crosspovidone (6%) was found to be the optimized combination. Stability studies were carried out at 25°C±20°C/60%±5% RH and 400°C±20°C/75%±5% RH for formulation L6 for 60 days. The results of stability studies indicated no significant changes with respect to physicochemical properties, in vitro disintegration time, wetting time and in vitro drug release.Keywords
Fast Dissolving Tablets, Pravastatin Sodium, Superdisintegrant, Direct Compression, Sodium Starch Glycollate, Crosscarmellose Sodium, Crosspovidone.- Evaluation of disintegrating properties of Borassus flabellifer Mucilage
Abstract Views :207 |
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Authors
Affiliations
1 JJT University, ZhunZhunu- Rajasthan, IN
2 Visveswarapura Institute of Pharmaceutical Sciences, Bangalore, IN
1 JJT University, ZhunZhunu- Rajasthan, IN
2 Visveswarapura Institute of Pharmaceutical Sciences, Bangalore, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 4, No 4 (2012), Pagination: 227-239Abstract
Plant products serve as an alternative to synthetic products because of local accessibility, eco friendly nature and lower price compared to imported synthetic products. Natural gums and mucilage have been widely explored as pharmaceutical excipients. Tablet disintegration has received considerable attention as an essential step in obtaining fast drug release. The present study was undertaken to isolate mucilage from Borassus flabellifer endosperm and explored its use as disintegrant by formulating tablets of metformin. Extracted Mucilage was subjected to toxicity studies for its safety and preformulation studies for its suitability as a disintegrating agent. The extracted mucilage is devoid of toxicity. No chemical interaction between drug and excipients was confirmed by FTIR, TLC and DSC studies. Mouth dissolving tablets of metformin were prepared and compared with different concentrations viz; 0.5,1, 1.5, 2.0 and 2.5%(w/w) of Borassus flabellifer mucilage powder and Ac-Di-Sol®. The prepared tablets were characterized by FTIR, TLC and DSC studies. Ten formulations were prepared and evaluated for physical parameters such as thickness, hardness, friability, weight variation, drug content, disintegration time and drug dissolution. The formulated tablets had good appearance and better drug release properties. The study revealed that Borassus flabellifer mucilage powder was effective as disintegrant in low concentrations (1%). The mucilage was found to be a superior disintegrating agent than Ac-Di-Sol®. Studies indicate that the extracted mucilage may be a good source of pharmaceutical adjuvant, specifically a disintegrating agent.Keywords
Borassus flabellifer Mucilage, Natural Excipient, Metformin HCL, Disintegrant, Croscarmellose Sodium.- Isolation and Evaluation of Anacardium occidentale Gum as a Binding Agent in Tablet Formulations
Abstract Views :207 |
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Authors
Affiliations
1 Department of Pharmaceutics, K.L.E.S's College of Pharmacy, Ankola-581314, IN
2 Principal KM Kundnani College of Pharmacy, Cuffe Parade, Mumbai, IN
3 Department of Pharmaceutics, K.L.E.S's College of Pharmacy, Ankola- 581314, IN
1 Department of Pharmaceutics, K.L.E.S's College of Pharmacy, Ankola-581314, IN
2 Principal KM Kundnani College of Pharmacy, Cuffe Parade, Mumbai, IN
3 Department of Pharmaceutics, K.L.E.S's College of Pharmacy, Ankola- 581314, IN